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Job Details

Senior Scientist

Science and Research



San Diego, California, United States

4 FDA approved drugs; 15+ clinical candidates; 400+ patents; 20 years of Novartis Institutes for Biomedical Research - San Diego (NIBR - SD) history! For over 21 years, NIBR - SD has been doing cutting-edge innovative drug discovery for the Novartis global research organization.<br><br>The candidate will join a dynamic team involved in the design and synthesis of oligonucleotides for Novartis’s drug discovery programs. This individual will be responsible for the independent operation and maintenance of instruments to synthesize, purify, and analyze chemically modified oligonucleotides for in vitro and in vivo studies. Successful candidates have experience with modern laboratory equipment and spectroscopic analysis, preferably in relation to oligonucleotides, and ability to work on multiple projects in multi-disciplinary team settings. The ideal candidate is a personable and organized team player who thrives in a fast-paced environment. This role provides you with the opportunity to take on increasing responsibility over time within Novartis Global Discovery Chemistry.<br><br>Primary Responsibilities:<br>• Collaborate with scientists throughout the organization on the discovery and advancement of innovative oligonucleotide therapeutics<br>• Operate oligonucleotide synthesizers, HPLC, and LC-MS for synthesis, qualitative analysis, and purification of synthetic oligonucleotides to produce high quality oligonucleotides for research and drug development programs<br>• Critical analysis and evaluation of data to optimize synthesis yield, purity, and formulation of modified oligonucleotides<br>• Quantitate compounds spectroscopically for in vitro and in vivo experiments <br>• Develop quality control mechanisms and monitoring systems as well as maintain the equipment to ensure consistent and reliable production of oligonucleotides with minimal down time<br>• Manage procurement and inventory of chemicals and supplies for oligonucleotide synthesis<br>• Curate and maintain the inventory of synthesized oligonucleotides<br><br>Vaccine Policy: While Novartis does not require vaccination at this time, for certain Novartis sites in the US all associates and candidates may be required to either upload an image of their COVID-19 vaccine card demonstrating proof of full vaccination for COVID-19 (or other similar evidence of vaccination) or proof of a negative COVID-19 test taken by the associate or candidate within the past seven days to enter any of our sites and/or customer office or healthcare facility, as well as prior to participating in other work related off-site meetings. Employees working in customer-facing roles must adhere to and comply with customers’ (such as hospitals, physician offices, etc.) credentialing guidelines, which may require vaccination. <br><br><br>[#video#{#400,300#}#/video#]