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Job Details

Bristol Myers Squibb

Senior Scientist, Systems Neuroscience

Science and Research



Cambridge, Massachusetts, United States

Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more:

When you join BMS, you are joining a diverse, high-achieving team united by a common mission.

The Neuroscience TRC is committed to development of transformational therapeutics for patients with neurodegenerative and neuromuscular diseases. We have built a network of external partnerships across multiple treatment modalities (small molecules, biologics and RNA targeting) that leverage our leadership in protein homeostasis and inflammation to attach neurological diseases. Internal research focuses on protein homeostasis by direct and ligand directed degradation, neuroinflammation and remyelination.

Areas of interest include, but are not limited to, the following approaches:

Disease modifying therapies for neurodegenerative, neuro-inflammatory and neuromuscular diseases; CNS targets that modulate protein homeostasis, protein clearance, inflammation and reduce or eliminate toxic protein production; Emerging technologies (RNA, DNA targeting, gene regulation, editing and replacement, vector optimization) that when matched to underlying disease genetics can deliver a precision medicine portfolio with a high probability of success to address unmet medical needs; Targets in orphan/rare neurological and neuromuscular diseases. AI/ML in target identification and neurology drug discovery; Translational tools and technologies such as digital neuroimaging and fluid biomarkers to track neurodegenerative diseases; Novel blood brain-barrier delivery technologies.

Here, you’ll get the chance to grow and thrive through opportunities that are uncommon in scale and scope. You’ll pursue innovative ideas while advancing professionally alongside some of the brightest minds in biopharma.

Position Summary:

Reporting to the Scientific Director, Systems Neuroscience in Early R&D, the Senior Scientist will be part of the Neuroscience Thematic Research Center (Neuro-TRC). The emphasis will be on ensuring program team deliverables as outlined in a disciplined biomarker plan for clinical development. Consistent with the overall Neuroscience TRC externalized model, the individual may also guide one or more novel biomarker development projects. These efforts will focus on the context of use in neurodegeneration with a focus on movement disorders, including but not limited to Parkinson’s disease, amyotrophic lateral sclerosis, and multiple sclerosis. The Senior Scientist will be interfacing with internal and external partners for the development of novel biomarker to provide quantitative digital outcome measures. To accomplish these tasks, the Senior Scientist will support contracting as necessary (CROs, academics, consortia in the precompetitive space), data analysis to ultimately ensure delivery of clinically meaningful biomarkers. The individual will also contribute to innovation projects focused on generating pilot data that informs feasibility of new outcome measures transformational to the field.

The successful candidate will have a well-established track record of constructively interacting within project teams (e.g., clinical research physicians, preclinical toxicology, pharmacokinetic/pharmacodynamic line functions, statisticians, computational biologists), and with contract research organizations and other external experts to deliver science that supports the development of medicines to patients in need.

Position Responsibilities:

In the role as a Senior Scientist within the Systems Neuroscience group, the ideal candidate will:

  • Utilize existing human datasets relevant to aging/neurodegenerative disorders to explore/design new validation studies for digital biomarker development.

  • Work closely with the Systems Neuroscience lead to evaluate external potential partners (contract research organizations, start-ups, academics, consortia, foundations) for quality of work, data analysis and delivery, determining high priority digital data collection activities.

  • Aid in developing relevant scope of work and contracts to support the above efforts.

  • Aligning with the Systems Neuroscience team, design and oversee implementation of translational activities in proof-of-concept clinical studies conducted by clinical program teams.

  • Provide guidance on clinical and nonclinical biomarker data analysis to Global Biometrics, and Informatics and Predictive Sciences.

  • Prepare and deliver presentations within BMS and externally.

  • Develop/maintain knowledge of the current literature, propose novel concepts and targets.

  • Publish in scientific journals and present in scientific meetings as aligned with the Systems Neuroscience objectives.

Experience =

Basic Qualifications:

  • Bachelor’s Degree

    • 7+ years of academic and / or industry experience


  • Master’s Degree

    • 5+ years of academic and / or industry experience


  • Ph.D. or equivalent advanced degree in the Life Sciences

    • 2+ of academic and / or industry experience

Preferred Qualifications:

  • PhD and 2+ years of relevant industry experience in drug discovery and development or Master’s with 5+ years of relevant industry experience in drug discovery and development

  • Embraces being highly accountable for timelines and deliverables

  • Solid understanding of the principles of clinical study design and execution

  • Detailed knowledge and track record (as evidenced by publications in peer-reviewed journals) in biomechanical modeling of human function, especially movements

  • Familiarity with and strategic use of methodologic approaches for analyzing individual and population-based datasets so as to inform feasibility and proof-of-concept study designs

  • Experience in scaling models as soon as there is conviction of value added

  • Significant experience developing written proposals, scope of work and contracts to support collaborative research; successful track record of obtaining research grants

  • General understanding of drug development

  • Excellent oral and written presentation skills

  • Ability to work well within a dynamic matrixed team environment



If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as “Transforming patients’ lives through science™ ”, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

On-site Protocol
Physical presence at the BMS worksite or physical presence in the field is a necessary job function of this role, which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and it enhances the Company culture.

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to Visit to access our complete Equal Employment Opportunity statement.

BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.