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Job Details

Bristol Myers Squibb

Senior Principal Scientist Translational Research

Science and Research



Cambridge, Massachusetts, United States

Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more:

Bristol-Myers Squibb is a global Biopharma company committed to a single mission: to discover, develop, and deliver innovative medicines focused on helping millions of patients around the world in disease areas such as oncology, cardiovascular, immunoscience and fibrosis.

Join us and make a difference. We hire the best people and provide them with a work environment that places a premium on diversity, integrity, collaboration and personal development. Through a culture of inclusion, we create a better, more productive work environment. We believe that the diverse experiences and perspectives of all our employees help to drive innovation and transformative business results.

The Mechanisms of Cancer Resistance (MoCR) Thematic Research Center (TRC) in Cambridge is one of the fundamental research and early development engines delivering oncology therapeutics to patients. The scientists at this state-of-the-art R&D site focus on novel targets and pathways for tumors that are refractory to current Immuno-Oncology and Oncology therapies and implement our discovery platforms across all of our therapeutic focus areas. We partner closely with colleagues in Translational Medicine, Informatics and Predictive Sciences and Early Clinical Development to generate biomarker and patient enrichment hypotheses to enable efficient decision making in early clinical trials. Ultimately, our goal is to accelerate the translation of scientific knowledge and insights into the next wave of transformational medicines for cancer patients.

We are seeking an individual with translational expertise to join the Translational Research (TR) team within the Mechanisms of Cancer Resistance Thematic Research Center (MoCR TRC) at Bristol-Myers Squibb in Cambridge, MA

This individual will bring diverse scientific expertise, clinical development knowledge and experienced in matrix-based management to advance programs from lead initiating/optimization through IND enabling activities and ultimately to Clinical Proof of Concept. He/she is expected to build the biomarker plan including target engagement and pharmacodynamic (PD) markers, patient enrichment strategies and translate preclinical hypothesis into clinical implementation. This individual may serve as a translational asset lead, accountable/responsible for executing on translational and biomarker strategies and delivering biomarker data for an ongoing clinical program at MoCR.

Position Responsibilities

  • Lead the development and execution of high-quality translational and biomarker plans for target engagement, pharmacodynamics, patient enrichment strategy, and rational combination partner selection.
  • Utilize in vitro and in vivo platforms e.g. ELISA, IHC, NGS to interrogate target prevalence, mechanism of action for biomarker discovery in early programs and to conduct reverse translational research for clinical programs.
  • Ensure biomarker plans meet established program standards (within budget, on schedule, compliance, etc.) and build strategic partnership with cross-functional stakeholders
  • Execute, analyze, and communicate clinical biomarker data.
  • Review relevant section of clinical development plans, study reports, clinical trial protocols, lab manual and regulatory documents.

Desired Experience

  • Ph.D , with 6-8+ years of relevant industry experience in drug discovery and translational drug development, biologics preferred.
  • Knowledgeable in oncology and/or immuno-oncology disease area, demonstrate scientific acumen and mechanistic understanding of cancer biology
  • Excellent verbal and written communication skills
  • Comfortable working in a fast-paced environment where speed is paramount
  • Demonstrate ability to effectively influence stakeholders in a dynamic, matrixed organization.
  • Working knowledge of all functional areas of drug development.
  • Experience in managing CRO and/or external collaboration

If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as “Transforming patients’ lives through science™ ”, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

On-site Protocol
Physical presence at the BMS worksite or physical presence in the field is a necessary job function of this role, which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and it enhances the Company culture.

COVID-19 Information
To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.

BMS is dedicated to ensuring that people with disabilities can perform complex functions through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application, or in any part of the recruitment process, direct your inquiries to Visit to access our complete Equal Employment Opportunity statement.

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.