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Senior Scientist –Sickle Cell Disease; Hematology

Science and Research



Cambridge, Massachusetts, United States

Sickle cell disease (SCD) is the most common genetic hematological disorder, accounting for over 305,000 births in 2010, with millions of people affected across the globe centralizing in low and middle income countries. The condition can cause extreme pain, life-threatening infections and other complications such as stroke or loss of vision. The disease can drastically impact the quality of life of inflicted individuals. While the standard of care is treatment of symptoms, we are pursuing gene therapy as a potential cure for sickle cell disease (SCD). As the innovation engine of Novartis, the Novartis Institutes for Biomedical Research (NIBR) is collaborating with the Bill and Melinda Gates Foundation to develop in vivo gene therapies for SCD.<br> <br>Do you want to be part of a team that brings together NIBR drug discovery, innovation, and gene therapy expertise with funding support from the Gates foundation; focusing on early drug discovery projects that translate into medical revolution for Sickle Cell Disease? The Immuno-Oncology and Hematology (IOH) department at NIBR is looking for a highly motivated senior scientist\\newly graduated PhD candidates to join a team developing innovative, transformative in vivo therapies for Sickle Cell Disease. IOH is a highly dynamic and collaborative research department that interfaces innovative biology, genetic engineering, viral and non-viral delivery platforms, and genome analysis for pre-clinical drug development and translational medicine. <br><br>Your key responsibilities:<br>Your responsibilities include, but are not limited to:<br>• A crucial role in the development of novel therapeutic concepts and will contribute at all stages of a project, from inception, early project validation, optimization, candidate selection and through early clinical development of novel medicines for patients with sickle cell disease<br>• Culturing cell lines and establishing in vitro assays for hematopoietic stem and progenitor cells from human and mouse primary sources <br>• Independently designing, executing, and interpreting experiments <br>• Executing in vivo pharmacology studies according to IACUC and NIBR guidelines<br>• Coordinating and collaborating with other Novartis departments, external academic and business partners, and CROs to conduct research studies<br>• Maintaining detailed documentation of experiments in the NIBR electronic system<br><br>[#video#{#400,300#}#/video#]<br><br>The pay range for this position at commencement of employment is expected to be between $92,800 and $139,200 year; however, while salary ranges are effective from 1/1/23 through 12/31/23, fluctuations in the job market may necessitate adjustments to pay ranges during this period. Further, final pay determinations will depend on various factors, including, but not limited to geographical location, experience level, knowledge, skills and abilities. The total compensation package for this position may also include other elements, including a sign-on bonus, restricted stock units, and discretionary awards in addition to a full range of medical, financial, and/or other benefits (including 401(k) eligibility and various paid time off benefits, such as vacation, sick time, and parental leave), dependent on the position offered. Details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base salary (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.