Senior Principal Scientist/Associate Director CV Remodeling and Targeted Delivery

Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us

When you join BMS, you are joining a diverse, high-achieving team united by a common mission.

The Immunology and Cardiovascular Thematic Research Center (TRC) at BMS is one of the fundamental Research and Early Development (R&ED) units delivering therapeutics to patients. Our mission is to create transformative medicines of tomorrow based on the cutting-edge science of today. We leverage BMS’s internal invention engine that includes industry-leading expertise in small molecule chemistry, protein biotherapeutics, cell therapy, protein degradation, nucleic acids, and other therapeutic modalities. We work closely with our Research and Early Development colleagues in clinical and non-clinical development, project management, translational medicine, and informatics to advance therapies based on a deep understand of causal human biology. Further, we collaborate across the biopharmaceutical ecosystem to establish partnerships that complement our internal expertise.

Here, you’ll get the chance to grow and thrive through opportunities that are uncommon in scale and scope. You’ll pursue innovative ideas while advancing professionally alongside some of the brightest minds in biopharma.

Position Summary

BMS seeks a highly motivated, creative and collaborative Cardiovascular Disease Biologist with a focus on molecular disease mechanisms and tissue specific delivery to support research efforts to identify and characterize novel therapeutic targets, support mechanism-based drug development and develop platforms to specifically target novel therapies and modalities to the heart for the treatment of cardiovascular disease.

The successful candidate will work collaboratively with teams within CV Discovery in Brisbane, CA to support BMS’s Cardiovascular Research and Early Discovery efforts. The applicant is required to have a strong background in the molecular pathogenesis of cardiovascular diseases, adverse cardiac tissue remodeling, and oligonucleotide technologies. Knowledge of and experience with the structure and function of the sarcomere is a strong plus. This position provides an exciting opportunity to be a part of and grow with a core function within the CV Discovery Biology Department. In this role, the candidate will have an excellent opportunity to learn and develop a career in drug discovery process from target ideation to clinical development.

Key Responsibilities

• Applies expertise in cardiovascular disease mechanism and pathophysiology (eg. calcium handling, sarcomere function, fibrosis, hypertrophy, etc) to design experiments, lead projects and contribute to overall direction of CV Remodeling group.
• Independently initiates and leads new exploratory projects to drug novel CV Disease targets.
• Presents supportive arguments for highly complex ideas and projects to internal governance bodies and external stakeholders to seek endorsement.
• Provides guidance, mentor, and develop junior scientists in role.
• Develops collaborations with different functional groups to advance drug discovery projects and develop targeted drug delivery platforms.
• Proactively fosters relationships across disciplines and participates in the decision-making process for completion of team goals.
• Maintains up to date working knowledge of principles and theories, applying such knowledge to the research projects that supports Company interests.
• Demonstrating technical proficiency, scientific creativity, and independent thought in suggesting experimental design and research strategy.
• Organizes Departmental and group meetings, mentor fellow Scientists and foster safe work environment and direct collaborative efforts.
• Adapt quickly to adjust workload and priority based on project needs and assignments.

Basic Qualifications:

• Bachelor’s Degree
  • 10+ years of academic and / or industry experience

Or

• Master’s Degree
  • 8+ years of academic and / or industry experience

Or

• Ph.D. or equivalent advanced degree in the Life Sciences
  • 6+ years of academic and / or industry experience and 2+ years of leadership experience

Preferred Experience:

• Expertise in cardiovascular disease models and 8 years of relevant research experience in cardiovascular diseases and drug delivery.
• Knowledge of in vivo CV Disease models, targeted drug delivery and hemodynamics.
• Extensive experience working with phenotypic screening, target engagement assays, iPSC-derived/neonatal/adult cardiomyocyte models, and genetic intervention (knockdown/out, overexperession, editing)
• Deep knowledge of heart failure pathogenesis and general cardiovascular disease
• Experience of leading small team in cardiovascular disease research.
• Strong background in molecular and cellular biology for disease studies
• Ability to develop new techniques and methodologies as dictated by research need and introduce new technologies or methods to the team
• Ability to stay current with the scientific literature and state of the art, as well as interpret literature results in-light-of new findings
• Independence in problem solving and advancement of scientific projects toward common team goals
• Proven track records on building great relationships within functions and cross-functionally in collaborative environment.
• Exceptional communication, presentation, and data analysis skills.
• Generation of new experimental protocols that may require developing new methods

At BMS, our employees are committed to the following values:

• Integrity – We demonstrate ethics, integrity, and quality in everything we do for patients, customers, and colleagues
• Innovation – We pursue disruptive and bold solutions for patients
• Urgency – We move together with speed and quality because patients are waiting
• Passion – Our dedication to learning and excellence helps us to deliver exceptional results
• Accountability – We all own BMS’ success and strive to be transparent and deliver on our commitments
• Inclusion – We embrace diversity and foster an environment where we can all work together at our full potential

The starting compensation for this job is a range from $159,000 to $220,000, plus incentive cash and stock opportunities (based on eligibility). The starting pay takes into account characteristics of the job, such as required skills and where the job is performed. Final, individual compensation is decided based on demonstrated experience. For more on benefits, please visit our BMS Careers site. Eligibility for specific benefits listed in our careers site may vary based on the job and location.

Why You Should Apply

Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

Physical presence at the BMS worksite or physical presence in the field is an essential job function of this role which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and enhances the Company culture.

To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.

Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application or if you are applying to a role based in the U.S. or Puerto Rico and you believe that you are unable to receive a COVID-19 vaccine due to a medical condition or sincerely held religious belief, during or any part of the recruitment process, please direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as “Transforming patients’ lives through science™ ”, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

On-site Protocol
Physical presence at the BMS worksite or physical presence in the field is a necessary job function of this role, which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and it enhances the Company culture.

COVID-19 Information
To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.

BMS is dedicated to ensuring that people with disabilities can perform complex functions through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.