Senior Scientist, Discovery Oncology
Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.
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Bristol Myers Squibb is a world-leader in targeted protein degradation therapeutics. We are seeking a Senior Scientist who will join the Oncology Discovery team at Bristol-Myers Squibb at the Oncogenesis Thematic Research Center in San Diego, CA. We are seeking a highly collaborative, passionate, and motivated biologist with broad experience and understanding of target identification/validation and drug discovery processes for novel targets in oncology with a strong background cancer disease biology and manipulation of patient derived organoid models. The candidate will be part of a growing team focused on target validation, target biology support and development of complex tumor models (3D, matrix-attached, and/or organoid models) to enable novel targeted protein degradation drug discovery efforts. This laboratory-based position will support the development and characterization of cancer patient derived organoid models aligned with therapeutics areas of high need which will be utilized in target validation and drug discovery efforts. The candidate will be expected to work independently to design, interpret, and troubleshoot experiments, diligently document results, and exhibit strong verbal and written communication skills when presenting scientific results to multidisciplinary teams.
Develop, maintain, and passage patient derived material to enrich in-house organoid model libraries.
Develop and implement 3D bioprinting of complex tumor models.
Design and execute experiments to study novel oncology targets utilizing genetic and novel degrader-based perturbations.
Plan and run assays to measure cell growth, apoptosis, cell cycle, and protein levels.
Stay informed of cutting-edge science and clinical research landscape to assist with 3D model development and target validation.
Collaborate with colleagues in other functional areas including translational research, informatics and chemistry to pursue target validation experiments and support drug discovery efforts.
Maintain accurate electronic laboratory notebooks in a timely fashion and prepare technical reports, summaries, protocols, etc.
Present data at internal scientific meetings.
7+ years of academic and / or industry experience
5+ years of academic and / or industry experience
Ph.D. or equivalent advanced degree in the Life Sciences
2+ of academic and / or industry experience
Required technical expertise:
Deep understanding of cancer biology
3D Model Systems: experience with matrix-attached models, spheroids and/or organoids
BSL2+ mammalian cell culture: familiar with growing and assaying solid tumor cancer cell lines
Plate-based assays: cell viability assays (e.g. CTG), apoptosis assays (e.g. Caspase), Incucyte, etc.
Protein characterization: Western blot – WES/JESS is a plus, BCA, MSD assay and ELISA
CRISPR/Cas9-12/sgRNA/RNAi: Design, cloning, and implementation of stable knock-in/knock-out experiments in cell lines using transfection and lentiviral delivery.
FACS analysis: Apoptosis assays, cell cycle determination and multicolor staining
Computation: Windows, MS Office, GraphPad PRISM, FlowJo
Substantial experience in assay development and molecular biology
Attention to detail with excellent organizational and record keeping skills is a must.
Excellent oral and written communication skills, as well as the ability to effectively present scientific data
Other relevant experience:
Small molecule SAR experience
Industry experience with protein degradation technologies or ubiquitin biology is a plus
Automation: hands-on experience with cell seeders, compound printers, and other laboratory automation tools (e.g. Hamilton, Tecan instruments)
The starting compensation for this job is a range from $109,000 –$150,700, plus incentive cash and stock opportunities (based on eligibility).
The starting pay takes into account characteristics of the job, such as required skills and where the job is performed. Final, individual compensation is decided based on demonstrated experience.
For more on benefits, please visit our BMS Careers site.
Eligibility for specific benefits listed in our careers site may vary based on the job and location.
If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.
Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as “Transforming patients’ lives through science™ ”, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.
Physical presence at the BMS worksite or physical presence in the field is a necessary job function of this role, which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and it enhances the Company culture.
To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.
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