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Job Details

Bristol Myers Squibb

Senior Scientist: Computational and Systems Biology

Science and Research



San Diego, California, United States

Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more:

Job Description

We seek a collaborative and highly innovative computational scientist to join our Predictive Sciences team and develop cutting-edge computational strategies to analyze multi-omics perturbation data from compounds in our proprietary library to infer novel mechanism-of-action (MoAs) for oncology application.

This position will work alongside colleagues with other teams in the global Informatics and Predictive Sciences (IPS) group and play a key scientific role in elucidating compound MoA in our library at the level of cellular pathways and biological networks and predict their therapeutic effects on specific primary disease subtypes. We seek candidates who are passionate about learning a new drug discovery paradigm, bringing new medicines to the patients, and comfortable working in a fast-paced and highly collaborative environment.


  • Integrate multi-dimensional compound profiling data from proteomics, transcriptomics, and phenomics screens to elucidate compound activities
  • Infer compound MoA by mapping and analyzing compound perturbation in the context of cellular pathways and biological networks
  • Predict a compound’s therapeutic effect by linking compound perturbations with molecularly defined primary disease states.
  • Design and implement systems biology approaches to infer and prioritize novel drug targets.
  • Work with informatics and compound management team to manage compound screen and high throughput assay datasets.
  • Help create knowledge-graph from internal and external datasets to facilitate navigation of knowledgebase.
  • Author scientific reports, and present methods, results, and conclusions to publishable standard.
  • Contribute to planning and execution of collaborative projects with leading academic and commercial research groups worldwide.

Basic Qualifications

  • Bachelor's Degree in structural bioinformatics, computer science, engineering, or similar with 7+ years of academic / industry experience

  • OR Master's Degree in structural bioinformatics, computer science, engineering, or similar with 5+ years of academic / industry experience

  • OR PhD in structural bioinformatics, computer science, engineering, or similar with 2+ years of academic / industry experience

Preferred Qualifications:

  • Ph.D. in computational biology or systems biology with 2+ years of post-doctoral experience in applying computational and analytical approaches in university, pharma, or biotech settings, focusing on drug discovery, or elucidating underlying disease pathology.
  • Systems biology methods focused on both casual and correlative inferences.
  • Extensive experience in analyzing perturbation data from a wide variety of molecular profiles such as transcriptomics and proteomics in an integrative fashion.
  • Knowledge of various public perturbation repositories and ingestion of data from these repositories for internal use.
  • Ability to work with noisy and missing data to tease out relevant information.
  • Expertise in programming and scripting languages (R, Python, or Matlab).
  • Knowledge of various parametric and non-parametric statistical tests and ability to identify and apply the appropriate statistical test.
  • Excellent verbal and written communication skills.

Preferred Experience

  • Experience in machine learning/deep learning.
  • Knowledge of drug discovery in pre-clinical and early phase drug development stages

The starting compensation for this job is a range from $109,000-$150,700, plus incentive cash and stock opportunities (based on eligibility).

The starting pay rate takes into account characteristics of the job, such as required skills and the where the job is performed.

Final individual compensation will be decided based on demonstrated experience.

For more on benefits, please visit our

Eligibility for specific benefits listed on our BMS Careers site may vary based on the job and location.

If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as “Transforming patients’ lives through science™ ”, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

On-site Protocol
Physical presence at the BMS worksite or physical presence in the field is a necessary job function of this role, which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and it enhances the Company culture.

COVID-19 Information
To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.

BMS is dedicated to ensuring that people with disabilities can perform complex functions through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application, or in any part of the recruitment process, direct your inquiries to Visit to access our complete Equal Employment Opportunity statement.

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.