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Principal Scientist, Drug Discovery – Polycystic Kidney Diseases

Science and Research



Cambridge, Massachusetts, United States

6000! This is the number of associates in the Novartis Institutes for BioMedical Research (NIBR). This division is the innovation engine of Novartis, focusing on new technologies that have the potential to help produce therapeutic breakthroughs for patients.<br><br>The Disease Area x (DAx) department is accommodated within NIBR and is a group of about 145 scientists that work in collaboration with colleagues from Novartis Research and Development on several therapeutic areas with high unmet need, including kidney disease. Using a diverse array of approaches and ground breaking technology, DAx strives to develop drugs that improve the lives of individuals suffering from chronic kidney diseases for which there is currently no cure.<br><br>Impact of this Position:<br><br>We are seeking an innovative, independent and dynamic renal research scientist with broad expertise in molecular and cellular biology to join a discovery biology team focused on developing innovative therapeutic agents in the area of polycystic kidney disease (PKD).<br><br>Your responsibilities will include, but not limited to:<br><br>* Contribute to the NIBR drug discovery process with the goal to discover and develop novel therapeutic treatment options for patients with PKD.<br>* Conduct research in the area of PKD and provide leadership and innovation by acting as a subject matter expert on genetic cystic kidney diseases.<br>* Lead early drug projects in the renal disease space, propose and champion new targets and novel approaches for disease treatment. Act as a leader of a team tasked with the triage and validation of new biology knowledge harnessed from genome wide and pharmacological screens in complex 3D human model systems.<br>* Design and execute in vitro and in vivo research plans to evaluate targets modulating renal cyst expansion, inflammation and fibrosis.<br>* Develop assays and implement new technologies to enable the delivery of high quality data-driven package and enable project decisions a/o portfolio transitions. * <br>* Record and interpret experimental data, and present results to project team members.<br>* Engage in interdisciplinary research requiring the application of specialized scientific knowledge and advanced laboratory techniques, in particular engineered complex cellular models and their use with chemical biology and gene editing approaches.<br>* Collaborate with other scientists in a global matrixed dynamic environment fostering innovation and advance project activities. Develop and maintain external relationships/contacts.<br>* Deliver impact to projects by identifying technical trends, both internal and external to your subject area.<br><br>The pay range for this position at commencement of employment is expected to be between: $107,200.00 and $186,000.00 USD per year; however, while salary ranges are effective from 1/1/23 through 12/31/23, fluctuations in the job market may necessitate adjustments to pay ranges during this period. Further, final pay determinations will depend on various factors, including, but not limited to geographical location, experience level, knowledge, skills and abilities. The total compensation package for this position may also include other elements, including a sign-on bonus, restricted stock units, and discretionary awards in addition to a full range of medical, financial, and/or other benefits (including 401(k) eligibility and various paid time off benefits, such as vacation, sick time, and parental leave), dependent on the position offered. Details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base salary (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.