Senior Scientist - Protein Science

Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.

When you join Bristol Myers Squibb (BMS), you are joining a diverse, high-achieving team united by a common mission.

Key Responsibilities

• Interact with research program leaders in biology, chemistry, and scientists in Protein Science and Molecular Structure & Design to formulate a protein construct design strategy to enable protein structure determination by cryoEM and X-ray crystallography.
• Provide direction for gene synthesis and molecular cloning work performed by CROs.
• Express recombinant proteins and protein complexes in small scale tests and large scale production runs using eukaryotic hosts (e.g., baculovirus-infected insect cells and transiently-transfected mammalian cells)
• Purify proteins and protein complexes using automated chromatography workstations (e.g., AKTA Pure) and multi-dimensional purification strategies.
• Use various analytical techniques to inform and drive construct design, protein expression, and protein purification efforts towards homogeneous, monodisperse proteins and protein complexes suitable for structure determination by cryoEM and X-ray crystallography.

Basic Qualifications

Bachelor’s degree and 7+ years of academic/industry experience

or

Master’s degree and 5+ years of academic/industry experience

or

Ph.D. and 2+ years of academic/industry experience

Preferred Qualifications

• Ph.D. in Biochemistry, Cell Biology, Molecular Biology, or related field with 2+ years of industry experience working in a laboratory-based research setting.
• Comprehensive understanding of molecular cloning, cell biology, and protein biochemistry
• Experience in protein engineering and design of constructs for recombinant protein expression
• Demonstrated knowledge and experience in recombinant protein expression, including the use of prokaryotic and eukaryotic expression hosts and the production of multi-protein complexes.
• Comprehensive knowledge of protein chromatography principles and experience purifying challenging proteins, including large proteins and complexes from low-abundance expression systems.
• Demonstrated experience producing proteins and protein complexes that have led to successful structure determinations by X-ray crystallography and cryoEM.
• Experience using analytical techniques to characterize proteins and protein complexes, including mass spectrometry, light scattering (e.g., DLS, SEC-MALS), and thermal stability assays (e.g., TSA, nanoDSF).
• Experience applying laboratory automation to protein expression, purification, and/or characterization is a plus.
• A record of scientific publication employing the skills listed above.
• Familiarity with experiment documentation using electronic lab notebook and laboratory information management system (LIMS) systems.
• Strong written and oral communication skills are required.
• Applicants should be detail-oriented, highly organized, and able to multi-task with multiple projects.

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If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as “Transforming patients’ lives through science™ ”, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

On-site Protocol
Physical presence at the BMS worksite or physical presence in the field is a necessary job function of this role, which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and it enhances the Company culture.

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.