Scientist - ADME

Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.

When you join BMS, you are joining a diverse, high-achieving team united by a common mission.

BMS encompasses a broad range of disciplines to enable a robust pipeline of drug candidates aimed at serious diseases. Chemistry is a core capability in Small Molecule & Drug Discovery with innovative scientists working in medicinal chemistry, radiochemistry, analytical chemistry, and large-scale synthesis. Within SMDD our Lead Discovery and Optimization (LDO) team is responsible for high throughput screening, compound storage and distribution, primary assays to support discovery programs, and compound profiling to explore drug liabilities in vitro. LDO scientists discover and adopt cutting edge assay technologies that utilize state-of-the-art automation to drive speed and efficiency. Our Molecular Structure and Design team embraces novel approaches to computer-aided drug design, machine learning, and structural biology. The integration of these disciplines provides a seamless and highly interactive environment for discovery scientists to learn, develop, and innovate. Working in partnership with our disease area experts in the Thematic Research Centers provides an exciting pathway to discover and deliver medicines to patients in need.

Here, you’ll get the chance to grow and thrive through opportunities that are uncommon in scale and scope. You’ll pursue innovative ideas while advancing professionally alongside some of the brightest minds in biopharma.

Scientist, ADME/MS Team, Leads Discovery and Optimization
Leads Discovery and Optimization (LDO) is a dynamic organization that supports the entire continuum of drug discovery from lead identification to clinical candidate delivery at Bristol Myers Squibb (BMS). LDO leverages state of the art technologies, complemented by deep subject matter expertise and broad scientific knowledge, to deliver innovative and comprehensive preclinical in vitro datasets to support our drug discovery pipeline in disease areas such as oncology, immunology, cardiovascular diseases, and cell therapy.

We are seeking a Scientist for the LDO ADME/MS (absorption, distribution, metabolism and excretion/mass spectrometry) group located in Princeton, NJ. The group’s mission is to accelerate hit finding, hit-to-lead and lead optimization efforts in small molecule drug discovery at BMS by leveraging its leading-edge ADME profiling and HTMS capabilities. In this hands-on role, the chosen individual will develop, implement and perform high throughput in vitro assays to evaluate the ADME and physicochemical properties of synthetic compounds of various modalities. Self-motivation, scientific curiosity, attention to details, and strong communication and problem-solving skills are required.
Responsibilities:
• Perform all aspects of high throughput ADME/property assays including cell culture, assay incubation, mass spectrometry analysis, data review and publication.
• Operate and troubleshoot automated liquid handling, liquid chromatography and mass spectrometry instrumentation.
• Actively participate in continuous improvement efforts in assay evolution, new assay design, technology evaluation and process optimization.
• Generate data to enable development of AI/ML models for ADME properties, develop next-generation ADME/property assays with more physiological relevance, and assays for new modalities such as targeted protein degraders.
• Work closely with others in cross-function teams to ensure timely delivery of high quality data.
Basic Qualifications:

Bachelor’s Degree with 5+ years of academic/industry experience, OR Master’s Degree with 3+ years of academic/industry experience, OR Ph.D. in a life science field.

Preferred Qualifications:
• Ph.D. in drug metabolism/bioanalysis, biochemistry or a related field with 1-2 years of relevant research or industry experience, OR a M.S. with 4+ years of relevant experience, OR a B.S. with 6+ years of relevant experience.
• Strong background in biochemistry, drug metabolism or bioanalysis is a must, and hands-on experience in cell culture, enzymology, assay development and LC-MS analysis is preferred.
• Excellent communication and interpersonal skills to effectively interface with others working in a matrix team environment are required.
• Proficiency in general computer software, as well as vendor-specific instrument control and data analysis tools is required.
• A working knowledge of allied disciplines such as medicinal chemistry, lab automation, high-throughput screening, data visualization and AI/ML model building is helpful.

If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as “Transforming patients’ lives through science™ ”, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

On-site Protocol
Physical presence at the BMS worksite or physical presence in the field is a necessary job function of this role, which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and it enhances the Company culture.

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.