Senior Scientist - Structural Biology/Protein Purification

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BMS encompasses a broad range of disciplines to enable a robust pipeline of drug candidates aimed at serious diseases. Chemistry is a core capability in Small Molecule & Drug Discovery with innovative scientists working in medicinal chemistry, radiochemistry, analytical chemistry, and large-scale synthesis. Within SMDD our Lead Discovery and Optimization (LDO) team is responsible for high throughput screening, compound storage and distribution, primary assays to support discovery programs, and compound profiling to explore drug liabilities in vitro. LDO scientists discover and adopt cutting edge assay technologies that utilize state-of-the-art automation to drive speed and efficiency. Our Molecular Structure and Design team embraces novel approaches to computer-aided drug design, machine learning, and structural biology. The integration of these disciplines provides a seamless and highly interactive environment for discovery scientists to learn, develop, and innovate. Working in partnership with our disease area experts in the Thematic Research Centers provides an exciting pathway to discover and deliver medicines to patients in need.

Here, you’ll get the chance to grow and thrive through opportunities that are uncommon in scale and scope. You’ll pursue innovative ideas while advancing professionally alongside some of the brightest minds in biopharma.

We are seeking a highly motivated individual with experience in protein purification to join the Structural Biology team in Princeton, NJ. The ideal candidate will work within a highly collaborative environment to purify proteins from various expression system for use in x-ray crystallography and single particle cryo-em experiments. This individual will be responsible for developing and executing protein chromatography and characterization techniques to deliver high quality proteins as part of our strategic commitment to capitalize on breakthroughs in structural biology for complex and difficult targets. Working in partnership with our disease area experts in the Thematic Research Centers provides an exciting pathway to discover and deliver medicines to patients in need.

• In the role as a Senior Scientist Protein Production within Structural Biology, the ideal candidate will be responsible for:
• Interact with research program leaders in biology, chemistry, and scientists in Protein Science and Molecular Structure & Design to formulate a protein construct design strategy to enable protein structure determination by cryo-em and x-ray crystallography.
• Purify proteins and protein complexes using automated chromatography workstations (e.g., AKTA Pure) and multi-dimensional purification strategies.

Use various analytical techniques to inform and drive construct design, protein expression, and protein purification efforts towards homogeneous, monodisperse proteins and protein complexes suitable for structure determination by cryo-em and x-ray crystallography.

Basic Qualifications:

Bachelor’s Degree with 7+ years of academic and / or industry experience

Or

Master’s Degree with 5+ years of academic and / or industry experience

Or

Ph.D. or equivalent advanced degree in the Life Sciences

2+ of academic and / or industry experience

Preferred Qualifications:

• Ph.D. in Biochemistry, Structural Biology, Molecular Biology, or related field with 2+ years of industry experience working in a laboratory-based research setting.
• Comprehensive understanding of molecular cloning, structural biology, and protein biochemistry
• Experience in protein engineering and design of constructs for recombinant protein expression
• Comprehensive knowledge of protein chromatography principles and experience purifying challenging proteins, including large proteins and complexes from low-abundance expression systems.
• Demonstrated experience producing proteins and protein complexes that have led to successful structure determinations by x-ray crystallography and cryo-em.
• Experience using analytical techniques to characterize proteins and protein complexes, including mass spectrometry, light scattering (e.g., DLS, SEC-MALS), and thermal stability assays (e.g., TSA, nanoDSF).
• Experience applying laboratory automation to protein expression, purification, and/or characterization is a plus.
• Experience with protein crystallization, or cryo-em techniques preferred.
• A record of scientific publication employing the skills listed above.
• Familiarity with experiment documentation using electronic lab notebook and laboratory information management system (LIMS) systems.
• Strong written and oral communication skills are required.
• Applicants should be detail-oriented, highly organized, and able to multi-task with multiple projects.

If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as “Transforming patients’ lives through science™ ”, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

On-site Protocol
Physical presence at the BMS worksite or physical presence in the field is a necessary job function of this role, which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and it enhances the Company culture.

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

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