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Senior Scientist, Biotransformation PK Sciences

Science and Research



Cambridge, Massachusetts, United States

This position is located at our Cambridge, MA site and will not have the ability to be located remotely.<br><br>More than 100,000 people across 140 countries are working for Novartis to discover, develop and successfully market innovative products to prevent and cure diseases, to ease suffering, and to enhance the quality of life.<br><br>The Pharmacokinetic Sciences (PKS) Department within the Novartis Biomedical Research Division (BR) in Cambridge, Massachusetts is looking for a laboratory-based scientist with experience in metabolite profiling to join their global biotransformation team (with groups in Europe and North America) to strengthen the department’s metabolite profiling and identification (metID) capabilities for small molecules and/or new modalities such as antibody drug conjugates, oligonucleotides, or peptides.<br><br>As a biotransformation scientist, you will develop state-of-the-art analytical methodologies using high resolution mass spectrometry and be familiar with the chromatography, structure elucidation, and data processing requirements needed to characterize metabolites of small molecules, intact proteins, oligonucleotides, and/or peptides. You will plan and execute tailored experiments, maintain the laboratory environment/instruments, and support the development of new technologies. You will also be expected to interact with and present your findings in team meetings, document your findings, and prepare internal reports.<br><br>As the successful candidate you will be adaptable, independently motivated, and challenge driven with a history that demonstrates strong interpersonal skills that encourage successful collaborative working relationships. In this role, you will work in a team environment to support programs through the conduct of drug metabolism studies designed to understand ADME properties, metabolite identification, biotransformation pathways, and routes of elimination for a diverse portfolio of therapeutic modalities.<br><br>As the ideal candidate you should have a good understanding of the drug discovery/development process and have the ability to design, oversee, and interpret various types of biotransformation studies. Furthermore, depending on the seniority of the successful candidate, you will represent the ADME line function in PKS sub-teams and project teams, collaborate in the preparation of external publications, and contribute to registration documents.<br><br>Your main accountabilities will include:<br>• Design and execution of biotransformation studies to assess metabolic pathways and structural elucidation of metabolites<br>• Organize and prepare experimental protocols and study reports with upload of results to a centralized database<br>• Presentation of key findings to project teams and/or other stakeholders<br>• Support discovery, pre-clinical, and clinical development studies (in vitro and in vivo) to aid drug candidate progression<br>• Assure quality standard guidelines and safe work practices are applied while working in the laboratories<br><br>[#video#•{#400,300#}#/video#]