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Research Scientist II, CGT Delivery (AAV & Lentiviral)

Science and Research

Scientist

No

San Diego, California, United States

Research Scientist II, CGT Delivery (AAV & Lentiviral)

Job ID

389370BR

Feb 29, 2024

USA

About the Role

Position is onsite in San Diego

\#LI-Onsite

About the Role

Novartis Biologics Research Center (BRC) is a leader at the cutting edge of innovative medicine development to improve patient lives. BRC builds the biologics pipeline in collaboration with Novartis Biomedical Research (NBR) Disease Areas and Platforms via a breadth of technologies for discovery of antibody, protein, gene therapy and RNA-based therapeutics.

We are seeking a highly motivated scientist to contribute to gene therapy development as part of the global community of investigators in the Cell & Gene Therapy (CGT) group within BRC. The successful candidate will work at the cutting edge of gene therapy delivery platform and technology and contribute to CGT Delivery programs. This role encompasses primarily lab-based responsibilities as outlined below. The scientist will take part in projects that will contribute to the development of novel capsid variants using internally developed screening platforms. The successful candidate with be a collaborative scientist with in-depth experience in cell and molecular biology, knowledge of virology (AAV and LVV) and assay development.

Key responsibilities:

• Participate and perform experiments in CGT Delivery including and not limited to molecular cloning and plasmid library production.

• Operate next-generation sequencing (NGS) platform instrumentation (Illumina, PacBio, etc.) and analyze data from targeted experiments is highly desired.

• Execute molecular biology assays to analyze in vitro and in vivo samples for characterization with techniques such as PCR/qPCR/dPCR, IHC/IF, and/or ELISA/MSD.

• Co-lead in vivo biodistribution and platform analysis projects as part of internal CGT programs.

• Develop molecular biology assays for the specific needs of internal CGT programs.

• Prepare quality data sets and reports adhering to the good research practices and quality culture across BRC.

• Present results at appropriate internal and external meetings and conferences.

*Multiple positions available.

Diversity & Inclusion / EEO

We are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Accessibility and Reasonable Accommodations: Individuals in need of a reasonable accommodation due to a medical condition or disability for any part of the application process, or to perform the essential functions of a position, please let us know the nature of your request, your contact information and the job requisition number in your message:

Role Requirements

• Scientific background with an BS in Biological Sciences or a closely related discipline with 1+ years of academic or industry lab related experience. Industry experience is preferred. Masters preferred.

• This lab-based position is located in San Diego, CA and will not have the ability to be located remotely.

• Experience with molecular biology techniques (such as and not limited to DNA, RNA isolation from NHP and mice tissues, cDNA synthesis, Biodistribution - ddPCR analysis, contribute towards in-vivo and in-vitro assays, ELISA, IHC, nucleic acid extraction, qPCR, transcriptomics) is required.

• Willingness to independently pursue assay and technological development to advance CGT.

• The position requires the ability to work collaboratively in a dynamic team centric scientific environment and adaptability to emerging project/group needs, excellent communication, and presentation skills, both written and verbal, and strong interpersonal skills

Desirable Requirements:

• Experience with operating next-generation sequencing (NGS) platform instrumentation (Illumina, PacBio, etc.) and analysis of short-read and long-read sequencing data is highly desired.

• Skills in measuring/performing viral expression, purification, quantification and detection, DNA and RNA sequencing are a highly desired.

• Experience with histological, immunohistochemical or immunofluorescence techniques is also preferred.

• Experience in animal models, CGT delivery, and molecular virology, mammalian cell culture and virus production, and purification is desired.

Why Novartis:

Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture

Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards

Commitment to Diversity & Inclusion: The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Novartis Compensation and Benefit Summary:

The pay range for this position at commencement of employment is expected to be between $80,000and $120,000/year; however, while salary ranges are effective from 1/1/24 through 12/31/24, fluctuations in the job market may necessitate adjustments to pay ranges during this period. Further, final pay determinations will depend on various factors, including, but not limited to geographical location, experience level, knowledge, skills, and abilities. The total compensation package for this position may also include other elements, including a sign-on bonus, restricted stock units, and discretionary awards in addition to a full range of medical, financial, and/or other benefits (including 401(k) eligibility and various paid time off benefits, such as vacation, sick time, and parental leave), dependent on the position offered. Details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base salary (as well as any other discretionary payment or compensation program) at any time, includ

Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture

Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network

Division

Biomedical Research

Business Unit

BIOLOGICS RESEARCH CENTER

Location

USA

Site

San Diego, CA

Company / Legal Entity

NIBRI

Functional Area

Research & Development

Job Type

Full Time

Employment Type

Regular

Shift Work

No