Principal Scientist, In vitro ADME

Principal Scientist, In vitro ADME

Job ID

Mar 04, 2024

USA

About the Role

Internal Role Title: Principal Scientist I

Job Location: Emeryville, CA (onsite)

About the role:

We are actively seeking a dynamic and collaborative Principal Scientist to lead the development and execution of in vitro ADME assays for the evaluation of potential therapeutics at our Emeryville, California site. You will possess prior experience in designing and conducting in vitro ADME assays for drug candidate optimization, demonstrating proficiency in LC-MS, enzyme kinetic measurements, and cell culture. A solid understanding of small molecule drug discovery processes is essential, and participation in a drug discovery project is preferred.

Key Responsibilities:

• Conduct comprehensive in vitro ADME screening assessments for candidate drug molecules, covering microsome stability, CYP inhibition, permeability, plasma protein binding, and transporter assays.

• Collaborate closely with other DMPK team members to ensure the timely delivery of high-quality data guiding drug candidate selection.

• Drive innovation by developing new ADME assays to address complicated project questions and support the optimization of new drug modalities.

• Design and execute in vitro experiments addressing project-specific issues related to compound metabolism and interaction with enzymes/transporters.

• Translate in vitro ADME data into human in vivo predictions

• Contribute to analytical LC-MS/MS method development, bioanalysis, and troubleshooting.

• Present key findings to project teams and collaborators, while also coordinating and preparing experimental protocols and study reports for compound progression.

Diversity & Inclusion / EEO

We are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Accessibility and Reasonable Accommodations: Individuals in need of a reasonable accommodation due to a medical condition or disability for any part of the application process, or to perform the essential functions of a position, please let us know the nature of your request, your contact information and the job requisition number in your message:

• Novartis: e-mail [email protected] or call +1 [Register to View]
• Sandoz: e-mail [email protected] or call: +1-[Register to View]

Role Requirements

What You'll Bring to the Role:

• PhD with at least 2 years, or BS/MS with at least 10 years of related post-graduate experience in a scientific field, whether in academia, contract research organizations, or the pharmaceutical industry.

• Strong technical understanding of DMPK principles, with expertise in in vitro ADME assay design and translation to in vivo findings.

• Proven experience designing and executing in vitro assays to optimize the ADME properties of drug candidates.

• Hands-on experience with LC-MS (preferably Sciex) for sample analysis, and proficiency in using various software (Excel, GraphPad Prism, Analyst) for data analysis and graphics.

• Extensive background in investigating enzyme kinetics, determining parameters such as Km, Vmax, Ki, and Kinact.

• Desirable experience with long-term hepatocyte co-culture systems such as HepatoPac.

• Excellent interpersonal, organizational, oral/written communication, and teamwork skills.

• Demonstrated ability to work independently in a fast-paced environment with strong multitasking capabilities.

Why Novartis: Our purpose is to reimagine medicine to improve and extend people’s lives and our vision is to become the most valued and trusted medicines company in the world. How can we achieve this? With our people. It is our associates that drive us each day to reach our ambitions. Be a part of this mission and join us! Learn more here: https://www.novartis.com/about/strategy/people-and-culture

You’ll receive: You can find everything you need to know about our benefits and rewards in the Novartis Life Handbook: https://www.novartis.com/careers/benefits-rewards

Commitment to Diversity and Inclusion / EEO: The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Novartis Compensation and Benefit Summary: The pay range for this position at commencement of employment is expected to be between $112,800- $169,200/year; however, while salary ranges are effective from 1/1/24 through 12/31/24, fluctuations in the job market may necessitate adjustments to pay ranges during this period. Further, final pay determinations will depend on various factors, including, but not limited to geographical location, experience level, knowledge, skills, and abilities. The total compensation package for this position may also include other elements, including a sign-on bonus, restricted stock units, and discretionary awards in addition to a full range of medical, financial, and/or other benefits (including 401(k) eligibility and various paid time off benefits, such as vacation, sick time, and parental leave), dependent on the position offered. Details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base salary (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.

Join our Novartis Network: If this role is not suitable to your experience or career goals but you wish to stay connected to hear more about Novartis and our career opportunities, join the Novartis Network here: https://talentnetwork.novartis.com/network

Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture

Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: https://talentnetwork.novartis.com/network

Division

Biomedical Research

Business Unit

Global Discovery Chemistry

Location

USA

Site

Emeryville, CA

Company / Legal Entity

NIBRI

Functional Area

Research & Development

Job Type

Full Time

Employment Type

Regular

Shift Work

No