Senior Research Scientist ( MERCUSR112319ENUS)
We are seeking a highly motivated Senior Research Scientist to join the Chemical Biology Department in Discovery Chemistry organization at our company's Research Laboratories. The successful candidate will work closely with scientists in the Department and with colleagues in Chemistry, Quantitative Biosciences, Genetics and Pharmacogenomics and Disease Area Biology.
He or she will be a key contributor to our chemical biology proteomics efforts to characterize protein-protein, protein-ligand interactions and proteome-wide drug effects to elucidate drug-target mechanism of action, reveal on-target engagement/off-target selectivity, and to deconvolute biological target functions from chemical and genetic screens.
He or she will develop, implement and execute mass spectrometry- based quantitative proteomics experiments with optimal biological sample preparation protocols, process, analyze and interpret data using public and commercially available and/or in-house developed software packages.
The ideal candidate must be proactive, able to interpret complex proteomics data through integrating information from genetics, cellular pharmacology, chemistry and molecular biology, communicate and collaborate effectively with various project teams across scientific disciplines and functions to contribute to iterative experimental design and mechanistic hypotheses generation and testing.
The candidate is expected to regularly present internal updates and to contribute to our Research Division's publication strategy in high level peer-reviewed journals and international conferences. We look for people who are inspired by our mission and who would fit in well with the collaborative, rigorous and entrepreneurial spirit of the company culture.
- Ph.D. in proteomics, chemical biology or a related discipline; or M.S. with 5+ years or B.S, with 8+ years of working experience
Preferred Experience and Skills:
Deep expertise in mass spectrometry-based quantitative discovery proteomics workflows and associated proteomic data processing/analysis. This includes various labeling techniques, data acquisition methods and processing software packages. Experience in targeted proteomics assays is a plus
Multi-year, hands on experience with nLC systems and high-performance mass spectrometers; Hands-on experience in workflow automation using liquid handling robots (e.g. Hamilton or Agilent systems) is a plus
Hands-on experience in cell culture and biological sample preparation for proteomics or chemo proteomics applications; Experience in innovative cell culture techniques (3D culture, organoids, co-culture systems, etc.) and genetic manipulation of cells (e.g., siRNA, CRISPR, protein overexpression, etc.) is a plus
Experience with analysis and visualization of “big data” and a sound understanding of statistical concepts; Proficiency in statistical programming languages such as R or Python is a plus
Hands-on experience with methods related to protein homeostasis and/or application of biorthogonal chemistry, photochemistry and affinity pull-downs for target identification and validation is a plus
Highly self-motivated, creative and critical thinking to solve complex technical and scientific problems with excellent attention to detail, and strong organizational and communication (oral and written) skills; Strong publication record
Ability to work independently yet team-oriented and able to build strong relationships in highly collaborative, multidisciplinary teams to effectively drive early drug discovery initiatives
We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.
Who we are …
We are known as Merck & Co., Inc., Kenilworth, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.
What we look for …
In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit and diverse perspective to our organization. Together we will continue Inventing For Life, Impacting Lives while Inspiring Your Career Growth.
Invent. Impact. Inspire.
NOTICE FOR INTERNAL APPLICANTS
In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.
If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.
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