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Job Details


Bristol Myers Squibb

Director of Bioprocess Technology

Technology

Information Technology Director

No

Devens, Massachusetts, United States

At Bristol Myers Squibb, we are inspired by a single vision – transforming patients’ lives through science. In oncology, hematology, immunology and cardiovascular disease – and one of the most diverse and promising pipelines in the industry – each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

Principle objective of this position

To direct the design, execution and interpretation of inocula, seed train, bioreactor, centrifugation, chromatographic, filtration, and ultrafiltration/diafiltration experiments to support large-scale biopharmaceutical cGMP commercial manufacturing.

Major Duties and Responsibilities

  • Directs all components of the Upstream or Downstream group and also PLCMs within Devens Biologics Drug Substance MS&T. The successful candidate will lead a dynamic and highly technical team of engineers and scientists by setting appropriate objectives and priorities, overcoming obstacles, and timely delivering results. As DS MS&T, we participate in cross-functional teams and work independently to meet high-visibility, critical business objectives.
  • Accountable to optimize resources to design, execution and analysis of inocula, seed train, bioreactor, centrifugation, protein chromatography, viral inactivation, ultrafiltration/diafiltration, and filtration experiments and their interpretation.
  • Sets high standards to assure compliance with BMS Directives including safety, staff training, cGMPs, and quality systems documentation. May represent the Devens site during regulatory agency inspections.
  • Collaborates with other MS&T Process Champions, Biologics External Manufacturing, and Devens Manufacturing Technology regarding strategies for technical and operational improvements, investigation resolution, process validation, and laboratory troubleshooting.
  • Invests in the growth of the group, including current and future leadership, through assignment of development opportunities, coaching, mentoring, and administration of rewards and recognition.
  • Establishes business objectives the group, consistent with BMS’ biologics strategy.
  • Establishes high performance standards, defines clear accountability, and leads by developing, adopting, and supporting continuous improvement.
  • Actively communicates group’s activities and progress through varied technical and non-technical forums.

Knowledge and Skill

  • Ph. D. or equivalent experience with over 10 years directly related industry experience, documented by a solid history of technical accomplishments in the cell culture or protein purification fields, e.g. relevant experience in upstream/downstream process development or upstream/downstream manufacturing technical support.
  • Experience in the design, modification, and optimization of cell culture unit operations or bioseparations with a strong practical knowledge of the technologies related to inocula expansion, bioreactor fundamentals, centrifugation, chromatography, filtration, and ultrafiltration/diafiltration with clear awareness of current industry trends.
  • Experienced in development and technology transfer of processes for commercial biologic manufacturing.
  • Excellent verbal & written communications skills.
  • In-depth knowledge of regulatory requirements for filing Biologics in the US and Europe including past productive interactions with US and European regulatory agencies for the development and manufacture of biologics.
  • Direct involvement in securing a BLA or sBLA regulatory filing of a commercial facility or process.

Contacts

The Associate Directors of the lab teams reports to the Director of MS&T Bioprocess technology and is in direct contact with other senior leaders, including members of Process Development, Analytical, Quality, EH&S, and Manufacturing. A frequent interaction with stakeholders on other BMS sites and external industry and regulatory representatives is expected.

Decision-making (Take action, final decision, recommend)

Works on complex problems in which analysis of situations or data requires an in-depth evaluation of multiple factors. Typical activities include problem solving of process-related investigations, the preparation of study protocols and reports, the evaluation of new process technologies through the use of scale-down models, and in-depth understanding of data from manufacturing. Ensures budgets, schedules, and performance requirements are met.

Supervision Received

Works with minimal supervision on the accomplishment of agreed upon goals and objectives.

Establishes operational objectives and assignments and delegates assignments to subordinate managers.

Supervision Exercised

Directly: 3-8 exempt

#LI-Onsite

Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

Physical presence at the BMS worksite or physical presence in the field is an essential job function of this role which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and enhances the Company culture.

To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.

Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application or if you are applying to a role based in the U.S. or Puerto Rico and you believe that you are unable to receive a COVID-19 vaccine due to a medical condition or sincerely held religious belief, during or any part of the recruitment process, please direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.