Expert Science & Technology (Preclinical Formulation / Pharmaceutics)

Technical Research & Development is seeking a highly motivated individual to join the discovery pharmaceutics function, Chemical and Pharmaceutical Profiling (CPP), and contribute to the development of discovery compounds. This successful candidate will join an energizing and collaborative research environment working as part of cross functional drug discovery teams in providing a developability assessment of new chemical entities<br><br>The ideal candidate must be capable of working independently to execute pre-formulation activities for drug candidates. As such, strong competency in physical pharmacy, preclinical formulation development and biopharmaceutics is required to efficiently function in this role and in understanding the physicochemical properties of new chemical entities and implementing formulation strategies to maximize the exposure in preclinical in vivo studies. <br><br>The candidate must demonstrate and foster strong team spirit and promote knowledge exchange within and between teams. Furthermore, the candidate should be able to proactively manage the interactions of project related activities between CPP and other departments such as research, and pharmaceutical development. The candidate must ensure alignment with other departments and functions and 3rd parties, as appropriate. In order to accomplish this, the role requires timely communication of overall project information to the appropriate management level via oral and written communication and ensuring that the project team objectives are in alignment with functional objectives.<br><br>Your responsibilities will include, but are not limited to:<br><br>• Design and develop stage appropriate, fit-for-purpose preclinical formulations. This includes development of both oral and parenteral formulations on a small scale<br>• Screening of solubility and dissolution rate enhancing formulations such as nanosuspensions and amorphous solid dispersions<br>• Assessment of the performance of prototype formulations using in vitro tests such as dissolution, precipitation behavior, and stability<br>• Preparation of formulations for use in preclinical in vivo studies and authoring protocols describing preparation of formulations for use at internal and external formulation labs<br>• Basic drug substance characterization by techniques such as XRPD, DSC and TGA, DVS, PLM and UPLC. Assessment of the chemical and physical properties of small molecules, such as solubility, dissolution, particle size and chemical stability<br>• Routine lab support such as buffer and mobile phase preparation, pH meter calibration, and basic troubleshooting of lab equipment. Shipping and receiving of samples between other Novartis and external sites.<br><br><br>[#video#https://www.youtube.com/watch?v=Mo1vwtVPVA0{#400,300#}#/video#]