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Bristol Myers Squibb

Associate Director/Director, Quantitative Systems Pharmacology

Technology

Systems Administrator

No

Princeton, New Jersey, United States

Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us

The scientist in this role will establish a Quantitative Systems Pharmacology Neuroscience (QSP NS) capability to develop models of various scales, from target engagement up through disease-level QSP models, and apply them to support drug development. QSP modeling has become an important component of discovery and clinical development. QSP models are mechanistic, mathematical models, based on integration of non-clinical/clinical knowledge and data to represent varying scales of drug pharmacology from target binding and modulation through disease pathophysiology and multi-drug pharmacology. They can be applied to aid in target prioritization, therapeutic modality selection, chemical/biotherapeutic optimization, biomarker characterization, combination assessment, clinical trial design, and trial interpretation.

The individual in this role will have an important hands-on impact and leadership impact to develop a new strategic thrust for the mechanistic modeling group. They will be expected to have strong modeling skills to individually contribute to and leadership skills to direct the establishment of strategy for QSP NS, supporting clinical development both through their own efforts and utilizing external partners as needed. It is likely the individual in this role will take on direct reports as their support for the clinical portfolio grows, they extend capabilities with adjacent areas, and support discovery initiatives earlier in the pipeline. This leader will be a part of a broader Quantitative Systems Pharmacology and Physiologically Based Pharmacokinetics organization with a strong intellectual environment and capable colleagues. They will be expected to coordinate their approaches with the QSP&PBPK methods lead to harmonize and promote best practices in terms of model calibration, incorporation of rich data sources, platform development, and modeling strategies.

Responsibilities:

  • Provide leadership to and collaboration with multidisciplinary project teams to develop and apply QSP models
  • Demonstrate high proficiency in the development and application of QSP models to address drug discovery and development questions
  • Partner with external groups to accelerate the internal Systems Pharmacology efforts
  • Independently provide expert support to project teams to design, execute and interpret clinical studies
  • Independently collaborate with stakeholders to identify and interpret experiments critical for model development and refinement
  • Coordinate with the QSP&PBPK methods lead on methodologies for virtual population workflows and script-based analysis packages
  • Mentor and train junior scientists to develop and apply QSP models, work with external groups, and provide expert support to project teams
  • Establish standards of practice within the department
  • Participate, contribute, and/or lead departmental and R&D initiatives
  • Align disease area QSP strategy with organizational priorities
  • Collaborate with stakeholders in Discovery Biology to identify and interpret experiments critical for model development and refinement
  • Stay informed with emerging literature and science in the systems biology/pharmacology modeling and simulation sciences
  • Serve as a subject matter expert to both internal colleagues and the external scientific community
  • Build and maintain a personal track record of publication in the area of QSP
  • Establish and maintain effective collaborations with stakeholders in other functional areas
  • Maintain an active relationship with colleagues in Clinical Pharmacology & Pharmacometrics at the project level as well as in the advancement of Pharmacometrics

Position requirements:

  • Ph.D. in Engineering, Mathematics, Bioinformatics, Pharmacometrics, Systems Biology/Pharmacology or a related field.
  • For Director level, In addition to the Ph.D., 8+ years of mathematical modeling & computer simulation experience for biomedical/pharmaceutical applications. Experience within pharmaceutical industry or pharmaceutical consulting is preferred, post-doctoral may be considered depending on the totality of prior experience.
  • For Associate Director level, In addition to the Ph.D., 5+ years of mathematical modeling & computer simulation experience for biomedical/pharmaceutical applications. Experience within pharmaceutical industry or pharmaceutical consulting is preferred, post-doctoral may be considered depending on the totality of prior experience.
  • M.S. in appropriate field with significantly more experience may be considered
  • Prior managerial experience is highly desired
  • Excellent understanding of theory, principles and statistical aspects of advanced mathematical modeling and simulation
  • Good understanding of the basic principles of pharmacokinetics and pharmacodynamics
  • Ability to learn new areas of biological sciences and build on solid foundation of quantitative skills to develop QSP models
  • Ability to communicate internally and externally on topics related to CP&P and QSP is required
  • Ability to keep up to date with and propose the implementation of scientific and technological developments in the area of Systems Pharmacology/Biology
  • Hands-on experience with modeling software like MATLAB/SimBiology, JDesigner/Systems Biology Workbench, Entelos PhysioLab Platform, etc. Experience with MATLAB SimBiology would be particularly desirable
  • Experience with general programming and data analysis tools/languages such as MATLAB, R, Python, Julia, Spotfire, etc., is required
  • Desire to interact as a modeling and simulation expert across clinical development teams with experts from different functional areas (pre-clinical and clinical)
  • Knowledge of current practices and issues in pharmaceutical R&D in disciplines such as clinical pharmacology, bioanalytical, biopharmaceutics, and toxicology
  • Knowledge and expertise in relevant neurodegeneration and neuroinflammation biology is highly desirable. Strong knowledge in general immunology is also desirable.

Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

Physical presence at the BMS worksite or physical presence in the field is an essential job function of this role which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and enhances the Company culture.

To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.

Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application or if you are applying to a role based in the U.S. or Puerto Rico and you believe that you are unable to receive a COVID-19 vaccine due to a medical condition or sincerely held religious belief, during or any part of the recruitment process, please direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.