Merck Senior Scientist, Vaccine Modeling and Simulation in Rahway, New Jersey
Our Research Scientists are our Inventors. We identify and target steps in disease mechanisms or pathways that could be inhibited or enhanced. Our goal is to isolate a compound that is effective against a disease target. Using innovative thinking, state-of-the-art facilities and robust scientific methodology we collaborate to discover the next medical breakthrough.
We are seeking talented scientists to join the Quantitative Pharmacology and Pharmacometrics (QP2) Vaccines team in the role of Senior Scientist. In this role, you will apply quantitative approaches to develop and implement translational PK/PD strategies, characterize clinical pharmacokinetics and pharmacodynamics of new chemical entities and biologics, and perform clinical trial simulations to inform dose selection and go/no-go decisions. You will work in collaborative teams with more experienced scientists across disciplines, and are expected to have or develop expertise in one or more areas necessary to performing primary responsibilities including:
Being or supporting the lead representative for QP2 on vaccine discovery and/or development teams
Framing critical vaccine development questions and using quantitative methods for optimizing vaccine development
Developing and executing translational PK/PD approaches, population pharmacokinetic models, exposure-response models, quantitative system pharmacology (QSP) clinical trial design simulation, comparator modeling and other model-based analyses.
Data management and analysis
On the job you will develop a comprehensive understanding of global regulatory expectations for small molecules, biologics, and/or vaccines, including support for regulatory documents (INDs, CSRs, CTDs), and agency interactions. You will also develop leadership skills in areas such as mentoring, managing a program, project, or initiative. In addition to the responsibilities outlined above, Senior Scientists are expected to demonstrate good communication skills, collaborating within QP2 and with other functional areas, as well as with external vendors and partners, creating an aligned, quantitative framework to impact decisions of vaccine development teams.
Master or equivalent degree with at least four years of experience, where “experience” means having a record of increasing responsibility and independence in a similar role in pharmaceutical drug development or academia.
Ph.D. or equivalent degree - OR- a PharmD or equivalent degree with at least two years of experience / educational background relating to: PKPD, pharmacometrics, mathematics, statistics/ biostatistics, computational biology/chemistry, or chemical/biomedical engineering.
Proficiency in R, Matlab or other similar programing language
Professional working proficiency in written and verbal communication
Knowledge of basic immunology
Experience in performing population PK / PKPD analyses
Experience with standard pharmacometric software (e.g. NONMEM, Monolix, Phoenix, etc.)
Skills in experimental design, mathematical problem solving, critical data analysis/interpretation, and statistics
We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” and that great medicines can make a significant impact to our world. And we believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.
Merck & Co., Inc., Kenilworth, New Jersey, USA is known as “Merck” in the United States, Canada & Puerto Rico. We are known as “MSD” in Europe, Middle East, Africa, Latin America & Asia Pacific. We are a global biopharmaceutical leader with a diverse portfolio of prescription medicines, oncology, vaccines and animal health products.
We are driven by our purpose to develop and deliver innovative products that save and improve lives. With 69,000 employees operating in more than 140 countries, we offer state of the art laboratories, plants and offices that are designed to Inspire our employees as we learn, develop and grow in our careers. We are proud of our 125 years of service to humanity and continue to be one of the world’s biggest investors in Research & Development.
What we look for …
In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit and diverse perspective to our organization. Together we will continue Inventing For Life, Impacting Lives while Inspiring Your Career Growth.
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Flexible Work Arrangements:
1st - Day
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Number of Openings:
Requisition ID: R3829
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