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Merck Associate Principal Scientist in West Point, Pennsylvania

Job Description

Our Research Scientists are our Inventors. We identify and target steps in disease mechanisms or pathways that could be inhibited or enhanced. Our goal is to isolate a compound that is effective against a disease target. Using innovative thinking, state-of-the-art facilities and robust scientific methodology, we collaborate to discover the next medical breakthrough.

We are seeking an Associate Principal Scientist to join our Vaccine Analytical Research and Development Separations and Biochemical Analytics team located in West Point, PA. In this role, an individual will work with a team of scientists to conduct state-of-the-art analytical techniques, such as protein separations (Akta FPLC, HPLC and CE), spectroscopic techniques (NMR, UV-VIS / IR / Fluorescence), virology, and classical wet chemistry techniques. The individual should also have in-depth knowledge of protein structure characterization, including protein-binding interactions, epitope mapping, protein folding kinetics to facilitate vaccine development. Lab automation / informatics is considered a plus.

The responsibilities of this role will be to lead assay development, drive scientific contributions at program levels, mentor scientist, and engage with product teams to characterize vaccines supporting process development, formulation development, vaccine investigations, method qualifications and transfers.

The incumbent must have strong analytical capabilities, communication skills, ability to lead other scientist, demonstrated scientific knowledge in peer review journals, and strong presentation skills. This incumbent should have knowledge in protein chemistry, structural biology, and biochemistry with applications to biomolecules such as viruses, virus like particles, proteins, DNA/RNA. The candidate must be able to prioritize and work in collaborative manner in a fast-paced, integrated, multidisciplinary team environment. Additional responsibilities include providing technical guidance to other scientists, evaluating new technologies, drive innovations to influence trends in industry, and preparing technical documents to support regulatory submissions.

Education Minimum Requirements:

  • A degree in Chemistry, Chemical Engineering, Biomedical Engineering, Biochemistry, Structural Biology or a closely-related field plus indicated experience are required: PhD with a minimum of 4 years post-degree Pharmaceutical industry experience OR Master’s with a minimum of 8 years Pharmaceutical industry experience.

Required Experience and Skills:

  • In-depth knowledge and understanding of chemistry and separations (HPLC, CE, LC-MS) demonstrated by publications.

  • Experience with protein characterization and protein interactions (Electrophoresis, SPR, ITC, MALS).

  • At least 3 years of experience with analytical method development, qualification and transfer.

  • Mentoring and leading junior scientists.

  • Ability to troubleshoot technical issues related to separation methodology.

  • Proven track record of publications with strong verbal & written communication skills.

  • Capable of multi-tasking and managing multiple projects.

  • Motivated to learn new skills, willingness to take on new challenges, and scientific curiosity.

Preferred Experience and Skills:

  • Experience with analysis of biological molecules.

  • Experience working in a good manufacturing practice (GMP) regulated environment.

  • Experience with method transfer.

  • Experience with assay robustness evaluation, method validation or qualification.

  • Familiar with International Council for Harmonisation (ICH) guideline of analytical procedure validation.

  • Solid computer skills, experienced with automated laboratory instrumentation, and independent analytical problem-solving capabilities.

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” and that great medicines can make a significant impact to our world. And we believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.


Who we are …

Merck & Co., Inc., Kenilworth, New Jersey, USA is known as “Merck” in the United States, Canada & Puerto Rico. We are known as “MSD” in Europe, Middle East, Africa, Latin America & Asia Pacific. We are a global biopharmaceutical leader with a diverse portfolio of prescription medicines, oncology, vaccines and animal health products.

We are driven by our purpose to develop and deliver innovative products that save and improve lives. With 69,000 employees operating in more than 140 countries, we offer state of the art laboratories, plants and offices that are designed to Inspire our employees as we learn, develop and grow in our careers. We are proud of our 125 years of service to humanity and continue to be one of the world’s biggest investors in Research & Development.

What we look for …

In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit and diverse perspective to our organization. Together we will continue Inventing For Life, Impacting Lives while Inspiring Your Career Growth.





In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.

US and Puerto Rico Residents Only

If you need an accommodation for the application process please email us at [email protected]

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We are an equal opportunity employer, Minority/Female/Disability/Veteran – proudly embracing diversity in all of its manifestations.

Search Firm Representatives Please Read Carefully

Merck & Co., Inc., Kenilworth, NJ, USA, also known as Merck Sharp & Dohme Corp., Kenilworth, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:




VISA Sponsorship:


Travel Requirements:

No Travel Required

Flexible Work Arrangements:


Not Indicated

Valid Driving License:

Hazardous Material(s):


Number of Openings:


Requisition ID: R53568