Scientist Protein Expression

At Bristol Myers Squibb, we are inspired by a single vision – transforming patients’ lives through science. In oncology, hematology, immunology and cardiovascular disease – and one of the most diverse and promising pipelines in the industry – each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

We are seeking a scientist with experience in mammalian protein expression to join the Protein Science group in the Discovery Biotherapeutics department in Cambridge, MA. The Discovery Biotherapeutics group supports programs across all BMS therapeutic areas, but works most closely in Mechanisms of Cancer Resistance, Cardiovascular and Immunoscience related therapeutics. The qualified candidate will be responsible for protein expression in transient and stable cell lines and will play a major role in support of the biotherapeutic discovery efforts at BMS. Activities include expression of discovery-enabling reagents, traditional candidate biotherapeutics, and highly engineered non-canonical biotherapeutics. Ideal candidates have a problem-solving mindset and are interested in contributing to program advancement. Our teams also make use of high throughput methods and automation to enhance productivity where possible.

Position Responsibilities:

• Protein expression in support of early to late stage discovery of novel biotherapeutics
  • Mammalian protein expression using both transient transfection and stable cell lines (HEK and CHO) in shake flasks and bioreactors
  • Stable CHO cell line generation and single cell cloning/sorting
  • Expression vector design
• Implementation of new expression systems and technologies
• Troubleshooting for challenging expression entities
• Help drive our strategy for producing and characterizing proteins to support various stages of the Discovery process
• Great data management, interpersonal and data sharing skills in a team environment are important
• General knowledge or downstream experience in Protein Purification and Characterization is desirable but not requisite.

Qualifications:

• Candidate should have a B.S. or M.S. in Biology, Engineering or a related field with at least 5-8 years of relevant experience in an industry setting.
• Experience with Mammalian protein expression in both shake flasks and bioreactors (Wave or stir tank) is required
• Experience with stable cell line generation is highly desired

Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

Physical presence at the BMS worksite or physical presence in the field is an essential job function of this role which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and enhances the Company culture.

To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.

Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application or if you are applying to a role based in the U.S. or Puerto Rico and you believe that you are unable to receive a COVID-19 vaccine due to a medical condition or sincerely held religious belief, during or any part of the recruitment process, please direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

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