Senior Scientist - Biomarker Development, Translational Medicine

38! Soluble Biomarkers contributed to advance science in 8 First In Human and >10 Proof of Concept studies. Data contributed to demonstrate pathway engagement, proof of biology and identify the right drug and the optimal dose for the right patient! 25 innovative soluble biomarker methods were developed in >5 disease relevant tissues. 1 purpose...to reimagine medicine! <br><br>This is an exciting opportunity to join the Molecular & Cellular Sciences (MCS) team within Biomarker Development (BMD) and Translational Medicine (TM) at the Novartis Institutes for Biomedical Research (NIBR). BMD focuses on delivering fit for purpose integrated biomarkers leveraging diverse expertise and knowledge in immunology, genomics, protein and cellular biology and state of the art data sciences.<br><br>Our innovative spirit enables the development and application of cutting-edge technologies which address key clinical questions such as target engagement, defining disease stage or progression, predict the safety or efficacy of medication, select a group of patients who would benefit most from a given therapy, and identify additional clinical indications suitable for a innovative molecule.<br><br>As a Senior Scientist within MCS in BMD, you will work in close collaboration with project and clinical teams to develop novel exploratory assays in our state of the art laboratories, implement internal and external biomarker activities and interpret results to enable proof of mechanism, proof of biology, safety and efficacy understanding. As a soluble biomarker assay expert, you will be developing and validating innovative biomarker solutions implementing new methodologies, delivering high quality data and playing a pivotal role in human clinical trials. <br><br>Your responsibilities will include, but not limited to:<br>•Development and validation of soluble biomarker assays with special focus on ligand binding assays (ELISA, MSD, Luminex) and other state of the art technologies. <br>•Implementation (sample measurement and data transfer) of validated biomarker assays in clinical studies.<br>•Generate and interpret data to enable proof of mechanism, dose selection & proof of biology across early clinical programs and present results at internal meetings<br>•Providing subject matter expertise to transition, implement and monitor assay development and validation at CROs <br>•Ensuring quality and timely delivery of data generated through outsourced activities<br>•Empowered for experimental design, execution, interpretation and reporting (oral and written) of assigned projects under Unbossed culture. <br>•Contributing to write quality reports and laboratory manuals.<br>•Cross training on a variety of biomarker modalities and technologies<br><br>Our Expectations<br>•Develop and validate fit-for-purpose soluble biomarker solutions <br>•Independently design, execute, and interpret experiments<br>•Ensure high quality and timely delivery of internal and external results <br>•Providing subject matter expertise for transferring, implementation and monitoring of soluble biomarker assay development, validation and sample analysis at external provider<br><br>[#video#https://www.youtube.com/watch?v=FIxJdzIn0mE{#400,300#}#/video#]