Associate Principal Scientist - Protein Engineering and New Modalities

Job Description

We are seeking a highly motivated and passionate scientist to join the Protein Engineering and Modalities group at our company in South San Francisco. You will employ protein engineering to improve tissue targeting specificity and therapeutic index of biotherapeutics and antibody drug conjugates. You will design molecules, coordinate production, plan experiments and through collaborations will test these molecules with the aspiration to build next generation therapeutics with ground-breaking properties. You will be part of a fast-paced and diverse team developing innovative protein therapeutics that will have a direct impact on patient lives.

Primary Responsibilities

• Function as biotherapeutics/protein-science co-leader of biotherapeutics and ADC drug discovery projects

• Invent and evaluate novel biotherapeutics and ADC formats

• Design molecules and participate hands-on in the production, characterization and optimization of biotherapeutics and ADCs

• Together with collaborators, test novel biotherapeutics and ADC formats preclinically

• Participate in target validation and discovery and generate project ideas

• Develop new applications for biotherapeutics and ADC modality

Position Qualifications:

Minimum Education Requirement:

• Ph.D. or equivalent with four or more years of professional experience or

• Master’s degree with 8 or more years of professional experience or

• Bachelor’s degree with 12 or more years of professional experience is required.

Preferred Experience and Skills:

• Deep understanding of tumor and tissue targeting of biotherapeutics and ADCs

• Strong background and hands-on experience in protein design, expression, purification, characterization and protein conjugation

• Experience with optimizing conditionally active and bispecific molecules is a plus

• Experience with imaging or bio-distribution studies is a plus

• Self-motivated and forward-thinking innovator with proven ability to work independently and collaboratively in a cross-functional team environment

• Team player with strong verbal and written communication skills

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

Who we are …

We are known as Merck & Co., Inc., Kenilworth, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.

What we look for …

In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit and diverse perspective to our organization. Together we will continue Inventing For Life, Impacting Lives while Inspiring Your Career Growth.

INVENT.

IMPACT.

INSPIRE.

NOTICE FOR INTERNAL APPLICANTS

In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.

Current Employees apply HERE

Current Contingent Workers apply HERE

US and Puerto Rico Residents Only:

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.

For more information about personal rights under Equal Employment Opportunity, visit:

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We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace.

Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Kenilworth, NJ, USA, also known as Merck Sharp & Dohme Corp., Kenilworth, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:

Relocation:

VISA Sponsorship:

Travel Requirements:

Flexible Work Arrangements:

Shift:

Valid Driving License:

Hazardous Material(s):

Number of Openings:

Requisition ID:R118007