Postdoctoral Research Fellow--Discovery Oncology

Job Description

New hires working in our US & Puerto Rico locations will be required to demonstrate that they have been fully vaccinated for COVID-19 or qualify for a medical or religious exemption or accommodation to this vaccination requirement, subject to applicable law.

Be a part of the legacy: Research Division Postdoctoral Research Fellow Program:

The company's Research Laboratories Postdoctoral Research Fellow Program aims to be a best-in-industry program for industrial postdoctoral researchers, designed to provide you with an academic focus in a commercial environment. With the resources, reach, and expertise of a large pharmaceutical company, postdoctoral researchers will be positioned to excel in an institution committed to breakthrough innovation in research and discovery.

Position Overview:

We are seeking a postdoctoral fellow that is passionate about mechanistic understanding of cellular and molecular interplays within tumor microenvironments that lead to response or resistance to various therapeutic approaches, using mouse models of human cancer. The goal of a postdoctoral fellow in this position will be to yield high quality publications and to implement the discovery of biological mechanisms into development of innovative therapeutics with various modalities, eventually to help patients with cancer. As a postdoctoral fellow in Discovery Oncology, s/he will work with a highly collaborative team of scientists from the multiple functional groups based in our Research Division in South San Francisco, California.

Responsibilities include but are not limited to:

• Employing complex in vivo disease model systems to address specific questions related to the pathogenesis of cancer and the mechanism of immune responses to it.

• Using cellular and molecular biology to implement in vitro and ex vivo techniques to dissect the mechanism of in vivo observations.

• Developing mouse models of human cancer to uncover biological mechanisms created by innovative therapeutics with novel modalities.

• Making efforts to understand interplays among different cell types within tumor microenvironments using various analytical approaches.

Education Minimum Requirement:

• PhD with less than 3 years of Postdoctoral Experience or achieved a Ph.D. by Spring/Summer of 2022 in Immunology, studying cancer or viral infection)

Required Experience and Skills:

• Sound knowledge, understanding, and experience in innate and adaptive immunity

• Direct experience and proficiency in handling of mice

• Experience in immune cell isolation and characterization using multi-color flow cytometry

• Basic statistical analysis skills

• Must be an independent, pro-active, and self-motivated scientist

• Close attention to details and excellent problem-solving skills

Preferred Experience and Skills:

• Experience in mouse syngeneic or/and spontaneous tumor models

• Direct experience with RNAseq, single-cell analyses, and bioinformatics is a plus

• Experience in biochemical/bioanalytical analyses on biological pathways, such as ELISA, ELISPOT, Luminex, MSD, Isoplexis, Seahorse, and Western blot

• Experience in immuno-oncology, inflammation, or/and chronic infection of pathogens

• Strong history of publication in peer-reviewed journals

Resume keywords:

Immunology, in vivo tumor, viral infection, cancer, multi-color flow cytometry, FACS

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

MRLpostdoc

Who we are …

We are known as Merck & Co., Inc., Kenilworth, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.

What we look for …

Imagine getting up in the morning for a job as important as helping to save and improve lives around the world. Here, you have that opportunity. You can put your empathy, creativity, digital mastery, or scientific genius to work in collaboration with a diverse group of colleagues who pursue and bring hope to countless people who are battling some of the most challenging diseases of our time. Our team is constantly evolving, so if you are among the intellectually curious, join us—and start making your impact today.

NOTICE FOR INTERNAL APPLICANTS

In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.

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Requisition ID:R154128