Postdoctoral Research Fellow--Molecular Discovery in Protein Sciences

Job Description

New hires working in our US & Puerto Rico locations will be required to demonstrate that they have been fully vaccinated for COVID-19 or qualify for a medical or religious exemption or accommodation to this vaccination requirement, subject to applicable law.

Be a part of the legacy: Postdoctoral Research Fellow Program

Our Research Laboratories’ Postdoctoral Research Fellow Program aims to be a best-in-industry program for industrial postdoctoral researchers, designed to provide you with an academic focus in a commercial environment. With the resources, reach, and expertise of a large pharmaceutical company, postdoctoral researchers will be positioned to excel in an institution committed to breakthrough innovation in research and discovery.

Position Overview:

We are seeking a talented and motivated Postdoctoral Scientist with expertise in molecular biology and a strong interest in antibody/biologics discovery and engineering to join the Molecular Discovery group as a part of the Protein Sciences Department at our Company's Discovery Biologics in Boston. The successful candidate will collaborate with the team to establish a novel bispecific/multi-specific VHHs (single domain antibodies) display platform for the discovery of the next generation of bispecific/multi-specific antibodies.

Responsibilities include but are not limited to:

• Lead the innovation and optimization to a novel bispecific/multi-specific VHH discovery platform by synthetic library and in vitro display approaches
• Identify the next generation of bispecific/multi-specific VHH for agonistic antibody, biparatopic antibody, and potential chimeric antigen receptor (CAR) applications
• Leverage the high-dimensional sequence data and structural information to identify patterns and correlations between bispecific/multi-specific VHH constructs and functions
• Coordinate and facilitate downstream lead production and characterization efforts
• Connect and build efficient working relationships within the Protein Sciences Boston and broader collaborations within our company's Research Laboratories
• Attend and actively participate in our company's internal scientific symposiums, seminars, workshops, and career development opportunities
• Present ideas and results through internal meetings, external conferences and publications

Education Minimum Requirement:

• Candidates must currently hold a PhD in molecular biology, biological sciences, biomedical sciences, or related field with less than 3 years of postdoctoral experience OR receive a PhD by Fall 2022.

Required Experience and Skills:

• Proficient in molecular biology and common molecular cloning techniques
• Strong analytical mindset, high attention to details, and creative in problem solving
• Excellent communication and collaborative skills for working in cross-functional multi-disciplinary teams

Preferred Experience and Skills:

• Good understanding of protein chemistry, protein engineering, and/or protein structure-function relationship
• Research experience with one or more of the following area is preferred:
• Discovery or engineering of biologics molecules such as VHHs, antibodies, bispecific/multi-specific antibodies, or non-antibody protein scaffolds
• Experience with synthetic biology, protein library design and assembly
• Hands-on experience in one or more in vitro display discovery methods (e.g. yeast, phage, mRNA, bacteria, mammalian), tissue culture, and cell-based assay development
• Familiar with handling and analyzing large dataset from next-generation sequencing is highly desirable but not required
• Experience of macromolecular structure modeling and dynamics is a plus

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

MRLpostdoc

Who we are …

We are known as Merck & Co., Inc., Kenilworth, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.

What we look for …

Imagine getting up in the morning for a job as important as helping to save and improve lives around the world. Here, you have that opportunity. You can put your empathy, creativity, digital mastery, or scientific genius to work in collaboration with a diverse group of colleagues who pursue and bring hope to countless people who are battling some of the most challenging diseases of our time. Our team is constantly evolving, so if you are among the intellectually curious, join us—and start making your impact today.

NOTICE FOR INTERNAL APPLICANTS

In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.

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We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace.

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Merck & Co., Inc., Kenilworth, NJ, USA, also known as Merck Sharp & Dohme Corp., Kenilworth, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

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Requisition ID:R155073