Postdoctoral Research Fellow – Discovery Neuroscience, Movement Disorders and Translational Capabilities

Job Description

Be a part of the legacy: Postdoctoral Research Fellow Program

Our Research Laboratories’ Postdoctoral Research Fellow Program aims to be a best-in-industry program for industrial postdoctoral researchers, designed to provide you with an academic focus in a commercial environment. With the resources, reach, and expertise of a large pharmaceutical company, postdoctoral researchers will be positioned to excel in an institution committed to breakthrough innovation in research and discovery.

What You'll Be Doing:

The Neuroscience Department is seeking postdoctoral fellowship applicants to be a part of an interdisciplinary team of drug discovery scientists within our Research Laboratories. Projects will seek to develop cell biology models and analytical methods to further understand cellular mechanisms pertinent to neurodegenerative disease, especially interrogating mechanisms of proteinopathy in Alzheimer’s and Parkinson’s disease linked to lipid dysregulation. Postdoctoral fellows will have the opportunity to explore the role of lipids in fostering disease phenotypes, in regulating cellular protein clearance pathways and in serving as conduits for discovery of disease biomarkers. Both in vitro and in vivo studies will be conducted to identify and validate cellular pathways relating to disease state using cell-based and rodent models. Candidates should have a strong background in neuroscience and in vitro techniques and a passion for interrogating the cellular mechanisms responsible for neurodegenerative disease. This fellowship is a unique opportunity to learn about the process of drug discovery while contributing to the advancement our drug development pipeline.

Responsibilities include but are not limited to:

• Working with disease area collaborators in the planning, execution and analysis of studies

• Conducting in vitro cell culture and biological specimen experiments and analysis using a variety of techniques including but not limited to protein labelling, immunoprecipitation, quantification and visualization, mRNA profiling, and genetic manipulation via siRNA or viral transduction

• Independent analysis and interpretation of data

• Communication of findings at project teams and external conferences as well as through peer-reviewed publications

What You Need:

• Candidates must currently hold a PhD OR receive a PhD by fall of 2021.

• Ability to conceive, design, execute and communicate complex experiments in the field of neuroscience as evidenced by publications

• Background in neuroscience, neurodegenerative disease, metabolic disease or related discipline

• Fluency in primary or recombinant cell culture and performing manipulations in cell models

• Fluency in in vitro lab techniques including protein, lipid, and/or mRNA extraction, measurement, & visualization.

• Must be an independent scientist with an ability to excel in a team environment

It's Great If You Have:

• Experience working with models of protein aggregation, misfolding, and/or lysosomal/mitochondrial dysfunction

• Experience performing lipid extractions and analytics using mass spectrometry

• Experience with rodent handling and rodent models of neurodegenerative disease

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” and that great medicines can make a significant impact to our world. And we believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

Who we are …

We are known as Merck & Co., Inc., Kenilworth, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.

What we look for …

In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit and diverse perspective to our organization. Together we will continue Inventing For Life, Impacting Lives while Inspiring Your Career Growth.

INVENT.

IMPACT.

INSPIRE.

mrlpostdoc

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We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace.

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Merck & Co., Inc., Kenilworth, NJ, USA, also known as Merck Sharp & Dohme Corp., Kenilworth, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

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Requisition ID:R126081