Postdoctoral Research Fellow – Metabolomics of Mitochondrial Dysfunction and Toxicity

Job Description

Characterization of Mitochondrial Dysfunction in Transgenic Rodent and Cell Models to Uncover Sensitive Biomarkers of Mitochondrial Diseases and Toxicity

New hires based in the US & Puerto Rico will be required to demonstrate that they have been fully vaccinated for COVID-19 or qualify for a medical or religious exemption or accommodation to this vaccination requirement, subject to applicable law.

Be a part of the legacy: Postdoctoral Research Fellow Program

Our Research Laboratories’ Postdoctoral Research Fellow Program aims to be a best-in-industry program for industrial postdoctoral researchers, designed to provide you with an academic focus in a commercial environment. With the resources, reach, and expertise of a large pharmaceutical company, postdoctoral researchers will be positioned to excel in an institution committed to breakthrough innovation in research and discovery.

Position Overview:

We are seeking a highly motivated and exceptional recent Ph.D. graduate to lead a postdoctoral project characterizing mitochondrial dysfunction in transgenic rodent and cell models to support drug discovery and development. A candidate who can apply their expertise in analytical chemistry and biochemistry to advance the project is highly desirable. The successful candidate will work as part of a highly collaborative and multidisciplinary research team under the supervision of two senior scientists with extensive experience in metabolomics, mitochondrial biology, and neuroscience. Research will be primarily carried out in the Analytical and Biochemical Toxicology (ABT) laboratory located in West Point, PA using state-of-the-art analytical capabilities, including NMR and LC-MS. The postdoctoral fellow will work in close collaboration with the Neuroscience Biology groups in our London and West Point sites. It is expected to be a 3-year research project leading to multiple peer-reviewed publications.

Responsibilities include but are not limited to:

• Conduct research under co-mentorship from ABT and Neuroscience Biology
• Design studies in transgenic rodent and cell models in close collaboration with in vivo neuro-pharmacologists and cell biologists
• Execute targeted in vitro and in vivo experiments while leveraging state of the art technologies and resources across our company's network to address fundamental questions regarding mitochondrial biochemistry and biomarkers
• Generate, organize, analyze, interpret data, and identify areas where key knowledge is lacking
• Effectively communicate results in oral presentations at internal and external events
• Independently draft and publish in peer-reviewed papers throughout the 3-year postdoctoral fellowship

Education Minimum Requirement:

• Candidate must have earned her/his Ph.D. within the last 2 years OR is expected to receive a Ph.D. by July 2022 in Analytical Chemistry, Biochemistry, Biology, or a related field.

Required Experience and Skills:

• Research experience in a number of different areas is welcomed, examples: NMR, LC-MS, mitochondria biology, neuroscience, in vitro or in vivo models
• Ability to quickly master new concepts and techniques
• Strong data analysis and presentation skills
• Must have excellent organizational, planning and prioritization skills
• Excellent verbal and written communication skills

Preferred Experience and Skills:

• Mitochondrial oxygen consumption rate and imaging analyses
• Cell culture and animal studies
• Stable isotope tracer analysis
• Statistical analysis
• Basic computer and computation skills

Resume keywords for recruiting team:

NMR, LC-MS, metabolomics, mitochondria, analytical chemistry, biochemistry

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

MRLpostdoc

Who we are …

We are known as Merck & Co., Inc., Kenilworth, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.

What we look for …

Imagine getting up in the morning for a job as important as helping to save and improve lives around the world. Here, you have that opportunity. You can put your empathy, creativity, digital mastery, or scientific genius to work in collaboration with a diverse group of colleagues who pursue and bring hope to countless people who are battling some of the most challenging diseases of our time. Our team is constantly evolving, so if you are among the intellectually curious, join us—and start making your impact today.

NOTICE FOR INTERNAL APPLICANTS

In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.

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Requisition ID:R160354