Senior Scientist – Cell Pharmacology and Bioanalytical Science

Job Description

Subject to applicable law, all prospective hires will be required to demonstrate that they have been fully vaccinated for COVID-19 or intend to be vaccinated for COVID-19 by November 1, 2021, or qualify for a medical or religious accommodation to this vaccination requirement. Hired candidates who are not vaccinated by November 1, 2021, and who have not been approved for a legally-required medical or religious accommodation will be subject to disciplinary action up to and including termination of employment, in accordance with applicable law.

Our Research & Development Division in South San Francisco is seeking a highly capable Senior Scientist with a strong background in cell pharmacology and bioanalytical science to join the Quantitative Biosciences department. The individual will design, execute, and interpret complex in vitro/ex vivo studies to support drug discovery across multiple disease areas. Successful candidates should demonstrate broad knowledge and technical expertise in pharmacology and bioanalytical method development/execution (HPLC, LC/MS, GC/MS, etc.), a strong track record of applying lipidomics/metabolomics approaches to pathway analysis and biomarker discovery, and the ability to integrate bioanalytical results with other data streams to drive mechanistic insight of target biology and therapeutic intervention. He or she should have a strong work ethic, excellent communication skills, and can work effectively in a collaborative cross-functional team environment.

Key responsibilities:

• Provide cell pharmacology and bioanalytical support for multiple therapeutic areas, including cardiometabolic, immunology, and oncology.

• Develop mechanistic and potency assays to characterize diverse targets/models/pathways and molecules, using advanced bioanalytical and pharmacological methods

• Design and execute lipidomics/metabolomics studies to assess metabolic changes under disease conditions and/or through therapeutic intervention, and to help elucidate mechanistic links between target engagement and disease phenotype

• Targeted/untargeted LC/MS assay development and optimization (for both cellular and tissue samples) on different platforms, MS data processing and analysis using various software, as wells as routine instrument maintenance and end-to-end technical troubleshooting

• Evaluate, develop, and implement new bioanalytical technologies and methods to improve workflow and enhance capabilities

• Leverage extensive lab automation to enhance assay quality and operational efficiency

• Drive scientific and technical innovations to enhance functional capability and productivity

• Represent Quantitative Biosciences department in multi-disciplinary project teams

• Collaborate extensively across our Research & Development Division network and with external partners to drive project progression toward milestones

Qualifications

Education Requirement:

• Ph.D. in Pharmacology, Biochemistry, Cell Biology or a related scientific discipline, with prior bioanalytical experience in a biotech or pharmaceutical setting

Experience Required

• Relevant knowledge and expertise in mechanistic pharmacology and cell model/assay development to support drug discovery

• Comprehensive skills in LC/MS and other bioanalytical methods, with a proven record of in-depth MS characterization and quantitation of small molecules and lipids

• Extensive method development experience in lipidomics/metabolomics and targeted LC/MS assays for a broad range of metabolites

• Hands-on experience with various sample preparation techniques, MS instrumentations (Waters, Thermo, etc.), and data analysis software

• In-depth understanding of lipid biochemistry and lipidomics applications in cardiometabolic and immuno-oncology drug discovery is highly desirable

• Familiarity with isotopic labeling and metabolic tracer/flux study methods is preferred

• Prior experience with automated liquid handling instruments (Multidrop, Bravo, Echo, etc.) for laboratory operation is a plus

• Demonstrated ability to work collaboratively in a cross-functional environment to advance drug discovery, with excellent organization and communication skills

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

Who we are …

We are known as Merck & Co., Inc., Kenilworth, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.

What we look for …

In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit and diverse perspective to our organization. Together we will continue Inventing For Life, Impacting Lives while Inspiring Your Career Growth.

NOTICE FOR INTERNAL APPLICANTS

In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.

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Merck & Co., Inc., Kenilworth, NJ, USA, also known as Merck Sharp & Dohme Corp., Kenilworth, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

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Requisition ID:R138643